Genotypes of SNPs of key genes regulate susceptibility and drug sensitivity to neovascular AMD in the human population.

ABSTRACT:

Objective

To compare the genetic characteristics of the normal control group to those of neovascular age-related macular degeneration (AMD) patients and to detect single-nucleotide polymorphisms (SNPs) related to the pathogenesis of neovascular AMD and the sensitivity to anti-VEGF drug, combercept.

Method

This is a prospective case-controlled study. A total of 104 neovascular AMD patients were treated with combercept and 106 normal subjects were served as the control group. SNPs associated with neovascular AMD and disease susceptibility and drug sensitivity were analysed.

Results

Significant differences existed between neovascular AMD patients and normal subjects among genotypes of the SNPs of two genes, ARMS2 (rs10490924 T) and HTRA 1 (rs11200638 A). The T alleles in

SUBMITTER: Cui J 

PROVIDER: S-EPMC11997823 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature