Association between chronic PM_2.5 exposure and neurodegenerative biomarkers in adults from critically polluted area.

ABSTRACT:

Background

Air pollution is a significant public health concern, increasingly recognized for its association with adverse health outcomes including neurodegenerative and neuroinflammatory conditions. The present study aimed to characterize plasma levels of key biomarkers related to neurodegeneration and neuroinflammation among middle-aged to elderly adults living in areas designated as critically polluted.

Methods

A total of 202 adults, aged 41 to 60 years, residing in CPA (CEPI > 70) for over ten years were recruited in the study. The exposures of air pollutant were measured as per the established protocols by CPCB. The plasma levels of neurodegenerative markers (Aβ_(1-42), Total τ, α-Synuclein, BDNF and GFAP) were estimated using commercially available ultra-sens

SUBMITTER: Balachandar R 

PROVIDER: S-EPMC11998342 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature