Clinical significance and immune infiltration analyses of the coagulation factor V gene in brain lower grade glioma.

ABSTRACT:

Background

Coagulation factor V (FV) is an essential cofactor in the coagulation cascade. However, the precise function of FV in lower grade glioma (LGG) is little known.

Methods

We first performed a pan-cancer investigation of FV expression and prognosis using TCGA and GTEx databases. Single-cell RNA sequencing confirmed FV expression in LGG tissues. We then investigated the mRNA expression level, prognostic value, and DNA methylation of FV in LGG using bioinformatics tools. The relationship between FV expression and tumor immune invasion was investigated using TIMER.

Results

FV was highly expressed in a variety of tumors, including LGG, and was associated with tumor prognosis. By combining a series of in silico analysis (including expression and survival analysis),

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12003246 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature