Sex-Specific Concordance of Striatal Transcriptional Signatures of Opioid Addiction in Human and Rodent Brains.

ABSTRACT:

Background

Opioid use disorder (OUD) has emerged as a severe, ongoing public health emergency. Current treatments for OUD are unsuccessful in leading to lasting abstinence in most users. This underscores the lasting effects of chronic opioid use and emphasizes the need to understand the molecular mechanisms of drug seeking and taking and how those alterations persist through acute and protracted withdrawal.

Methods

Here, we used RNA sequencing in postmortem human tissue from males (n = 10) and females (n = 10) with OUD and age- and sex-matched control subjects. We compared molecular alterations associated with human OUD in the nucleus accumbens (NAc) to mouse and rat models of nonvolitional (n = 4-5 per group per sex) and volitional (n = 5-6 per g

SUBMITTER: Shelton MA 

PROVIDER: S-EPMC12005289 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature