Sitagliptin phosphate ameliorates chronic inflammation in diabetes mellitus via modulating macrophage polarization.

ABSTRACT:

Aim

To investigate the effect and mechanism of Sitagliptin phosphate on inflammation and macrophage polarization in a mouse model of type 2 diabetes.

Methods

In vitro, Raw264.7 cells were cultured with a high concentration of glucose (HG) and sitagliptin phosphate (SIG). The levels of inflammatory factors and the regulation of macrophage polarization were investigated, and the differentially expressed genes between HG and HG+SIG intervention were analyzed and enriched through transcriptomics. In vivo, C57BL/6J male mice were treated with HFD+STZ to establish a type 2 diabetes mouse model were investigated the effects of regulation of macrophage polarization in the pancreas and visceral adipose tissue.

Results

In vitro cell experiments and transcriptomics

SUBMITTER: Hu X 

PROVIDER: S-EPMC12010097 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature