Probiotic treatment induces sex-dependent neuroprotection and gut microbiome shifts after traumatic brain injury.

ABSTRACT:

Background

Recent studies have highlighted the potential influence of gut dysbiosis on traumatic brain injury (TBI) outcomes. Alterations in the abundance and diversity of Lactobacillus species may affect immune dysregulation, neuroinflammatory responses, anxiety- and depressive-like behaviors, and neuroprotective mechanisms activated in response to TBI.

Objective

This study aims to evaluate the protective and preventive effects of Pan-probiotic (PP) treatment on the inflammatory response during both the acute and chronic phases of TBI.

Methods

Males and female mice underwent controlled cortical impact (CCI) injury or sham. They received a PP mixture in drinking water containing strains of Lactobacillus plantarum, L. reuteri, L. helveticas, L. fermentum, L. rhamnosus,

SUBMITTER: Holcomb M 

PROVIDER: S-EPMC12010691 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature