Meis transcription factors regulate cardiac conduction system development and adult function.

ABSTRACT:

Aims

The cardiac conduction system (CCS) is progressively specified during development by interactions among a discrete number of transcription factors (TFs) that ensure its proper patterning and the emergence of its functional properties. Meis genes encode homeodomain TFs with multiple roles in mammalian development. In humans, Meis genes associate with congenital cardiac malformations and alterations of cardiac electrical activity; however, the basis for these alterations has not been established. Here, we studied the role of Meis TFs in cardiomyocyte development and function during mouse development and adult life.

Methods and results

We studied Meis1 and Meis2 conditional deletion mouse models that allowed cardiomyocyte-specific elimination of Meis function during develo

SUBMITTER: Munoz-Martin N 

PROVIDER: S-EPMC12012448 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature