Exclusive enteral nutrition initiates individual protective microbiome changes to induce remission in pediatric Crohn's disease.

ABSTRACT: Exclusive enteral nutrition (EEN) is a first-line therapy for pediatric Crohn's disease (CD), but protective mechanisms remain unknown. We established a prospective pediatric cohort to characterize the function of fecal microbiota and metabolite changes of treatment-naive CD patients in response to EEN (German Clinical Trials DRKS00013306). Integrated multi-omics analysis identified network clusters from individually variable microbiome profiles, with Lachnospiraceae and medium-chain fatty acids as protective features. Bioorthogonal non-canonical amino acid tagging selectively identified bacterial species in response to medium-chain fatty acids. Metagenomic analysis identified high strain-level dynamics in response to EEN. Functional changes in diet-exposed fecal microbiota were further va

SUBMITTER: Hacker D 

PROVIDER: S-EPMC12017801 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature