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Identification of inverted U-shaped curve association between serum potassium and prodromal Parkinson's disease.


ABSTRACT:

Background

The association between serum potassium and prodromal Parkinson's disease (PPD) remains unclear currently.

Objective

The ultimate goal is to gain a deeper understanding of the implications of this association between serum potassium and PPD.

Methods

We conducted a retrospective cross-sectional study involving 1035 participants in PPMI cohort. Age, sex, education years, race, body mass index (BMI), calcium, alanine aminotransferase, aspartate aminotransferase, lymphocytes, neutrophils, serum uric acid, serum sodium, serum potassium, creatinine, serum glucose were obtained from all participants. Logistic regression, and smooth curve fitting were utilized to substantiate the research objectives.

Results

The overall PPD was 83.4 % (863/1035). Multivariat

SUBMITTER: Zhou W 

PROVIDER: S-EPMC12017917 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature

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