Systemic Lupus Erythematosus and Mortality in Elderly Patients With Early Breast Cancer.

ABSTRACT:

Objective

Patients with cancer and systemic lupus erythematosus (SLE) may have worse outcomes than those without SLE, given their comorbidities. We examined survival in elderly women with breast cancer (BC) and SLE and hypothesized that survival would be decreased compared with women with BC but without SLE.

Methods

We identified patients with BC and SLE and patients with BC without SLE in the Texas Cancer Registry and Surveillance, Epidemiology, and End Results, linked to Medicare claims. Overall survival (OS) was estimated after matching (age and cancer stage) and in multivariable Cox proportional hazards models adjusting for other cancer characteristics, treatment, and comorbidities. Two additional cohorts of women without cancer with and without SLE were also studied.

SUBMITTER: Bruera S 

PROVIDER: S-EPMC12019812 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature