Tumor-Infiltrating Clonal Hematopoiesis.

ABSTRACT:

Background

Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related condition associated with increased mortality among patients with cancer. CHIP mutations with high variant-allele frequencies can be detected in tumors, a phenomenon we term tumor-infiltrating clonal hematopoiesis (TI-CH). The frequency of TI-CH and its effect on tumor evolution are unclear.

Methods

We characterized CHIP and TI-CH in 421 patients with early-stage non-small-cell lung cancer (NSCLC) from the TRACERx study and in 49,351 patients from the MSK-IMPACT pan-cancer cohort. We studied the association of TI-CH with survival and disease recurrence and evaluated the functional effect of TET2-mutant CHIP on the biologic features of lung tumors.

Results

Among patients with NSC

SUBMITTER: Pich O 

PROVIDER: S-EPMC12021423 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature