DENSE-SIM: A modular pipeline for the evaluation of cine displacement encoding with stimulated echoes images with sub-voxel ground-truth strain.

ABSTRACT:

Background

Myocardial strain is a valuable biomarker for diagnosing and predicting cardiac conditions, offering additional prognostic information to traditional metrics such as ejection fraction. While cardiovascular magnetic resonance (CMR) methods, particularly cine displacement encoding with stimulated echoes (DENSE), are the gold standard for strain estimation, evaluation of regional strain estimation requires precise ground truth. This study introduces DENSE-SIM, an open-source simulation pipeline for generating realistic cine DENSE images with high-resolution known ground-truth strain, enabling evaluation of accuracy and precision in strain analysis pipelines.

Methods

This pipeline is a modular tool designed for simulating cine DENSE images and evaluating strain estima

SUBMITTER: Barbaroux H 

PROVIDER: S-EPMC12032873 | biostudies-literature | 2025 Summer

REPOSITORIES: biostudies-literature