Comparative effectiveness of surgery versus radiotherapy for non-nasopharyngeal head and neck lymphoepithelial carcinoma: An IPTW propensity score analysis.

ABSTRACT:

Background

Lymphoepithelial carcinoma (LEC) is a rare head and neck malignancy predominately treated with radiotherapy or surgery. However, comparative effectiveness studies, are lacking for non-nasopharyngeal head and neck LEC (HNLEC).

Methods

Patients diagnosed with non-nasopharyngeal HNLEC from 2000-2019 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Inverse probability of treatment weighting (IPTW) was used to balance baseline characteristics. Cancer-specific survival (CSS) was compared between surgery and radiotherapy groups using Kaplan-Meier analyses and Cox regression before and after IPTW adjustment.

Results

248 patients were included. Before IPTW adjustment, treatment modalities were not significantly associated with CSS

SUBMITTER: Zheng Z 

PROVIDER: S-EPMC12040192 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature