The Germline and Somatic Origins of Prostate Cancer Heterogeneity.

ABSTRACT:

Significance

This study uncovered 223 recurrently mutated driver regions using the largest cohort of prostate tumors to date. It reveals associations between germline SNPs, somatic drivers, and tumor aggression, offering significant insights into how prostate tumor evolution is shaped by germline factors and the timing of somatic mutations.

SUBMITTER: Yamaguchi TN 

PROVIDER: S-EPMC12046336 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature