A pairwise and network meta-analysis of anti-inflammatory strategies after myocardial infarction: the TITIAN study.

ABSTRACT:

Background and aims

Multiple anti-inflammatory drugs have been tested for secondary prevention after myocardial infarction (MI), giving mixed results and questioning the efficacy of anti-inflammatory therapy. No head-to-head comparisons between anti-inflammatory drugs have been performed. This study aimed to compare the efficacy and safety of anti-inflammatory drugs for secondary prevention after MI and the relative merits of specific drugs and administration strategies.

Methods and results

Randomized trials of anti-inflammatory therapy for secondary prevention after MI were identified. Primary efficacy and safety endpoints were trial-defined major adverse cardiovascular events (MACEs) and serious adverse events. Secondary endpoints included all-cause death, individual MACE

SUBMITTER: Laudani C 

PROVIDER: S-EPMC12046582 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature