Progression of aortic calcification among Japanese in Japan and white and Japanese Americans: a prospective cohort study.

ABSTRACT:

Aims

Continued low mortality from coronary heart disease in Japan, despite deleterious changes in traditional risk factors, remains unexplained. Since aortic calcification (AC) was an early predictor of cardiovascular mortality, we compared the progression and incidence of AC between Japanese in Japan, white Americans, and third-generation Japanese Americans in the ERA JUMP cohort. We examined whether higher blood levels of marine-derived n-3 fatty acids (FAs) in Japanese than in Americans accounted for the difference.

Methods and results

Men (n = 700) aged 40-49 years (252 Japanese in Japan, 238 white, and 210 Japanese Americans) were examined at baseline and 4-7 years later. AC was evaluated from the aortic arch to the iliac bifurcation with computed tomography and quantif

SUBMITTER: Li M 

PROVIDER: S-EPMC12054729 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature