Evolutionary responses of Escherichia coli to phage pressure: insights into mucoidy and colanic acid overexpression.

ABSTRACT:

Background

Antibiotic resistance is a major issue affecting all spheres of human activity, including agriculture. One significant example is the Avian Pathogenic Escherichia coli (APEC), a bacterium that infects poultry and leads to substantial economic losses in the farming industry. As antibiotics lose efficacity, bacteriophages (phages) -viruses that specifically target bacteria-are emerging as a promising alternative to antibiotics for treating and preventing bacterial infections. However, bacteria can develop resistance to phages through various mechanisms. Studying the coevolution between a phage and its host bacterium is important to gain insight into the phage's potential as a therapeutic agent. This study investigates the evolutionary responses of an APEC strain and a labo

SUBMITTER: Piche LC 

PROVIDER: S-EPMC12057083 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature