Complete sequencing of ape genomes.

ABSTRACT: The most dynamic and repetitive regions of great ape genomes have traditionally been excluded from comparative studies^1-3. Consequently, our understanding of the evolution of our species is incomplete. Here we present haplotype-resolved reference genomes and comparative analyses of six ape species: chimpanzee, bonobo, gorilla, Bornean orangutan, Sumatran orangutan and siamang. We achieve chromosome-level contiguity with substantial sequence accuracy (<1 error in 2.7 megabases) and completely sequence 215 gapless chromosomes telomere-to-telomere. We resolve challenging regions, such as the major histocompatibility complex and immunoglobulin loci, to provide in-depth evolutionary insights. Comparative analyses enabled investigations of the evolution and diversity of regions previo

SUBMITTER: Yoo D 

PROVIDER: S-EPMC12058530 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature