Sirt6 deficiency promotes senescence and age-associated intervertebral disc degeneration in mice.

ABSTRACT: Intervertebral disc degeneration is a major risk factor contributing to chronic low back and neck pain. While the etiological factors for disc degeneration vary, age is still one of the most important risk factors. Recent studies have shown the promising role of SIRT6 in mammalian aging and skeletal tissue health, however its role in the intervertebral disc health remains unexplored. We investigated the contribution of SIRT6 to disc health by studying the age-dependent spinal phenotype of mice with conditional deletion of Sirt6 in the disc (Acan^CreERT2; Sirt6^fl/fl). Histological studies showed a degenerative phenotype in knockout mice compared to Sirt6^fl/fl control mice at 12 months, which became pronounced at 24 months. RNA-Seq analysis of NP and AF tissue

SUBMITTER: Ramteke P 

PROVIDER: S-EPMC12059161 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature