<i>Parabacteroides distasonis</i> promotes liver regeneration by increasing <i>β</i>-hydroxybutyric acid (BHB) production and BHB-driven STAT3 signals.

ABSTRACT: The liver regenerative capacity is crucial for patients with end-stage liver disease following partial hepatectomy (PHx). The specific bacteria and mechanisms regulating liver regeneration post-PHx remain unclear. This study demonstrated dynamic changes in the abundance of Parabacteroides distasonis (P. distasonis) post-PHx, correlating with hepatocyte proliferation. Treatment with live P. distasonis significantly promoted hepatocyte proliferation and liver regeneration after PHx. Targeted metabolomics revealed a significant positive correlation between P. distasonis and β-hydroxybutyric acid (BHB), as well as hyodeoxycholic acid and 3-hydroxyphenylacetic acid in the gut after PHx. Notably, treatment with BHB, but not hyodeoxycholic acid or 3-hydroxypheny

SUBMITTER: Guo M 

PROVIDER: S-EPMC12069244 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature