Antithrombotic effect and plasma pharmacochemistry of Justicia Procumbens L.

ABSTRACT:

Importance

Justicia procumbens L. contains lignans with remarkable antiplatelet aggregation effects. Its ethyl acetate extract has demonstrated the efficacy of inhibiting platelet aggregation in preliminary tests. Identifying key components, elucidating the antithrombotic mechanism, and evaluating its potential for treating thrombotic diseases are of great significance.

Methods

Chemical analysis was conducted on the ethyl acetate extract of J. procumbens. Animal models of carotid artery and venous thrombosis, combined with proteomics analysis, were employed to study the antithrombotic mechanism.

Results

Chemical analysis identified justicidin B (JB) and chinensinaphthol methyl ether (CME) as the major active antithrombotic constituents. The extract inhibited platelet

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12083875 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature