Synergistic regulation of metal-organic cage architectures via temperature- and solvent-driven atropisomerism.

ABSTRACT: Regulating multistimulus responses in artificial systems remains a challenge in smart material development. We present a versatile chemical switching system that precisely controls the self-assembly of metal-organic cages via temperature and solvent changes. The key component, cyclo[2](1,3-(4,6-dimethyl)benzene) (4-pyridine)[6](1,3-(4,6-dimethyl)benzene) (CP2), was generated as three atropisomers (1, 2, and 3) with C_s, C₁, and C_2v symmetries. Thermally, metastable isomers (1 and 2) convert into the stable isomer (3), which reacts with Pd²⁺ to form specific molecular cages. Depending on the solvent, either rectangular M₂L₂ cages (5' and 5) for

SUBMITTER: Liang J 

PROVIDER: S-EPMC12088403 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature