G2D: a tool for mining genes associated with disease.
Ontology highlight
ABSTRACT: Background
Human inherited diseases can be associated by genetic linkage with one or more genomic regions. The availability of the complete sequence of the human genome allows examining those locations for an associated gene. We previously developed an algorithm to prioritize genes on a chromosomal region according to their possible relation to an inherited disease using a combination of data mining on biomedical databases and gene sequence analysis.Results
We have implemented this method as a web application in our site G2D (Genes to Diseases). It allows users to inspect any region of the human genome to find candidate genes related to a genetic disease of their interest. In addition, the G2D server includes pre-computed analyses of candidate genes for 552 linked monogenic diseases without an associated gene, and the analysis of 18 asthma loci.Conclusion
G2D can be publicly accessed at http://www.ogic.ca/projects/g2d_2/.
SUBMITTER: Perez-Iratxeta C
PROVIDER: S-EPMC1208881 | biostudies-literature | 2005 Aug
REPOSITORIES: biostudies-literature
Publications
G2D: a tool for mining genes associated with disease.
Perez-Iratxeta Carolina C Wjst Matthias M Bork Peer P Andrade Miguel A MA
BMC genetics 20050822
<h4>Background</h4>Human inherited diseases can be associated by genetic linkage with one or more genomic regions. The availability of the complete sequence of the human genome allows examining those locations for an associated gene. We previously developed an algorithm to prioritize genes on a chromosomal region according to their possible relation to an inherited disease using a combination of data mining on biomedical databases and gene sequence analysis.<h4>Results</h4>We have implemented th ...[more]
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