Cost-Effectiveness of α2 Agonists for Intravenous Sedation in Patients With Critical Illness.

ABSTRACT:

Importance

Propofol and the α2 agonists dexmedetomidine and clonidine are used for sedation in patients with critical illness receiving mechanical ventilation. Evidence about the cost-effectiveness of intravenous (IV) sedation with these medications is lacking.

Objective

To investigate the cost-effectiveness of dexmedetomidine-, clonidine-, and propofol-based IV sedation in patients with critical illness receiving mechanical ventilation.

Design, setting, and participants

This economic evaluation used within-trial cost-utility analysis with a 6-month time horizon comparing dexmedetomidine-, clonidine-, and propofol-based IV sedation from a UK National Health Service and Personal Social Services perspective, with individual-level data collected from the Alpha 2 Agonists

SUBMITTER: Morris S 

PROVIDER: S-EPMC12090026 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature