Silencing <i>TET1</i> expression alters the epigenomic landscape and amplifies transcriptomic responses to allergen in airway epithelial cells.

ABSTRACT: Previous studies have demonstrated that ten-eleven translocation methylcytosine dioxygenase 1 (TET1) plays a protective role against house dust mite (HDM)-induced allergic airway inflammation. TET1 transcriptionally responded to HDM extract and regulated the expression of genes involved in asthma in human bronchial epithelial cells (HBECs). How TET1 regulates the expression of these genes, however, is unknown. To this end, we measured mRNA expression, DNA methylation, chromatin accessibility, and histone modifications in control and TET1 knockdown HBECs treated or untreated with HDM extract. Throughout our analyses of multiomics data, we detected significant similarities between the effects of TET1 knockdown alone and the effects of HDM treatment alone, all enriched for asthm

SUBMITTER: Brown AP 

PROVIDER: S-EPMC12094077 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature