Dynamics of vector competence for dengue virus type 2 in rural and urban populations of Aedes albopictus: implications for infectious disease control.

ABSTRACT:

Background

Understanding the intrinsic factors that influence mosquito vector competence (VC) to pathogens is crucial for assessing the risk of disease transmission in both rural and urban environments. We assessed the VC of Aedes albopictus mosquitoes from urban (dengue-endemic) and rural (dengue-free) areas in Guangzhou, China, for dengue virus-2 (DENV-2), while also examining intrinsic factors such as Wolbachia and immune-related gene expression influencing VC.

Methods

Adult females of rural, urban, and laboratory (control) populations of Ae. albopictus were orally exposed to a freshly prepared suspension of the DENV-2 New Guinea C strain (GenBank: AF038403.1), with a final titer of 1 × 10⁷ plaque-forming units (PFU)/ml, for a period of 60 min. Three different

SUBMITTER: Khan J 

PROVIDER: S-EPMC12128243 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature