PIWIL2 downregulation in colon cancer promotes transposon activity and pro-tumorigenic phenotypes.

ABSTRACT: Reactivation of transposable elements (TEs) in somatic tissues, particularly of LINE-1, is associated with disease by causing gene mutations and DNA damage. Previous work has shown that the PIWI pathway is crucial for TE suppression in the germline. However, the status and function of this pathway is not well characterized in differentiated somatic cells and there is lack of consensus on the role of the pathway in somatic tumorigenesis. To shed light on this conundrum, we examined the PIWI pathway in colon cancer through combining bioinformatic analyses and cell-based assays. Shifted Weighted Annotation Network (SWAN) analysis revealed that the pathway experiences significant allelic losses in colon cancer and that PIWIL2, the main catalytic component of the pathway responsible for TE sile

SUBMITTER: Risner A 

PROVIDER: S-EPMC12139840 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature