Systematic identification of cancer-type-specific drugs based on essential genes and validations in lung adenocarcinoma.

ABSTRACT: Depicting a global landscape of essential gene-targeting drugs would provide more opportunities for cancer therapy. However, a systematic investigation on drugs targeting essential genes still has not been reported. We suppose that drugs targeting cancer-type-specific essential genes would generally have less toxicity than those targeting pan-cancer essential genes. A scoring function-based strategy was developed to identify cancer-type-specific targets and drugs. The EssentialitySpecificityScore ranked the essential genes in 19 cancer types, and 1151 top genes were identified as cancer-type-specific targets. Combining target-drug interaction databases with research/marketing status, 370 cancer-type-specific drugs were identified, bound to 100 out of all identified targets. Profiles of app

SUBMITTER: Lian X 

PROVIDER: S-EPMC12145228 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature