Combined [¹⁸F]Fluorodeoxyglucose PET and [¹²³I]Iodometomidate-SPECT for diagnostic evaluation of indeterminate adrenal neoplasias-the cross-sectional diagnostic test accuracy study FAMIAN.

ABSTRACT:

Background

Adrenal tumours are frequently detected by conventional imaging. However, computed tomography and magnet resonance imaging have limited specificity in classifying the most prevalent tumour type, adrenocortical adenoma (ACA), which typically does not require surgery. We proposed that combined molecular imaging with [¹⁸F]Fluorodeoxyglucose-positron emission tomography (FDG PET) and [^123I]Iodometomidate-single photon emission tomography (IMTO SPECT) improves non-invasive classification of ACA.

Methods

This cross-sectional, multicentre diagnostic study included patients (≥30 years) with non-functioning indeterminate adrenal masses (>3 cm or increase >1 cm, Hounsfield units [HU] ≥10 on unenhanced computed tomography [CT]) scheduled for surgery. Us

SUBMITTER: Hahner S 

PROVIDER: S-EPMC12148602 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature