The Natural History of Acanthamoeba Keratitis: A Systematic Literature Review.

ABSTRACT:

Introduction

Acanthamoeba keratitis (AK) was first identified in 1972 and the first patient cured with propamidine was reported in 1985. Treatment outcomes, before the advent of the first effective anti-amoebic treatment, were known to be poor and often required therapeutic keratoplasty (TK) but have not been evaluated in detail. Analysis of these outcomes has value for several reasons: it gives an historical perspective, describes the natural history of AK when the disease was minimally modified by the early treatments and provides a benchmark against which current treatments can be compared and how these have changed the therapeutic results.

Methods

We conducted a systematic literature review for the period 1970-1995 using PRISMA guidelines. The population of interest comp

SUBMITTER: Papa V 

PROVIDER: S-EPMC12167199 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature