Chromatin loops are an ancestral hallmark of the animal regulatory genome.

ABSTRACT: In bilaterian animals, gene regulation is shaped by a combination of linear and spatial regulatory information. Regulatory elements along the genome are integrated into gene regulatory landscapes through chromatin compartmentalization^1,2, insulation of neighbouring genomic regions^3,4 and chromatin looping that brings together distal cis-regulatory sequences⁵. However, the evolution of these regulatory features is unknown because the three-dimensional genome architecture of most animal lineages remains unexplored^6,7. To trace the evolutionary origins of animal genome regulation, here we characterized the physical organization of the genome in non-bilaterian animals (sponges, ctenophores, placozoans and cnidarians)^8,9 and their closest u

SUBMITTER: Kim IV 

PROVIDER: S-EPMC12221973 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature