Regulation of PV interneuron plasticity by neuropeptide-encoding genes.

ABSTRACT: Neuronal activity must be regulated in a narrow permissive band for the proper operation of neural networks. Changes in synaptic connectivity and network activity-for example, during learning-might disturb this balance, eliciting compensatory mechanisms to maintain network function^1-3. In the neocortex, excitatory pyramidal cells and inhibitory interneurons exhibit robust forms of stabilizing plasticity. However, although neuronal plasticity has been thoroughly studied in pyramidal cells^4-8, little is known about how interneurons adapt to persistent changes in their activity. Here we describe a critical cellular process through which cortical parvalbumin-expressing (PV⁺) interneurons adapt to changes in their activity levels. We found that changes in the ac

SUBMITTER: Selten M 

PROVIDER: S-EPMC12222018 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature