Urinary phytoestrogen levels and reduced thyroid hormone sensitivity: a cross-sectional analysis of NHANES 2007-2010.

ABSTRACT: Estrogen and thyroid hormone interact extensively in vivo, but the relationship between phytoestrogens and thyroid function and thyroid hormone sensitivity remains unclear. Using 2007-2010 NHANES data of United States, we analysed the association of six urinary phytoestrogens with thyroid function and thyroid hormone sensitivity using a weighted multivariate linear regression model. The final analysis included 2521 euthyroid participants. After weighted multivariable adjustment (excluding dietary patterns and serum iodine levels), urinary phytoestrogen concentrations showed significant sex- and compound-specific associations with both thyroid function indicators and thyroid hormone sensitivity indices. For thyroid function, in males, Equol and Enterodiol showed negative associations with f

SUBMITTER: Li Z 

PROVIDER: S-EPMC12225033 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature