Psychedelic 5-HT2A agonist increases spontaneous and evoked 5-Hz oscillations in visual and retrosplenial cortex.

ABSTRACT: Visual perception appears largely stable in time. However, psychophysical studies have revealed that theta waves (4-8 Hz) can modulate perception and have been linked to various cognitive states and functions. Neither the contribution of theta waves to cortical activity nor their impact during aberrant brain states have been resolved at high spatiotemporal scales. Here, using cortex-wide population voltage imaging in awake mice, we found that bouts of 5-Hz oscillations in the visual cortex are accompanied by similar oscillations in the retrosplenial cortex, occurring both spontaneously and evoked by visual stimulation. Injection of psychotropic 5-HT2AR agonist induced a significant increase in spontaneous 5-Hz oscillations, and also increased the power, occurrence probability and temporal

SUBMITTER: White CM 

PROVIDER: S-EPMC12236502 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature