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Bone Changes With Long-Acting Cabotegravir or Tenofovir Disoproxil Fumarate/Emtricitabine for HIV Prevention in Cisgender Men and Transgender Women: HPTN 083.

ABSTRACT: In a randomized clinical trial, pre-exposure prophylaxis (PrEP) with long-acting cabotegravir (CAB-LA) had a better bone safety profile than tenofovir disoproxil fumarate-emtricitabine (TDF-FTC) over 105 weeks. For individuals with low bone mineral density or other fracture risk factors, CAB-LA PrEP should be considered over TDF-based PrEP. Clinical Trials Registration.  clinicaltrials.gov (NCT02720094).

SUBMITTER: Brown TT 

PROVIDER: S-EPMC12249367 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature

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Bone Changes With Long-Acting Cabotegravir or Tenofovir Disoproxil Fumarate/Emtricitabine for HIV Prevention in Cisgender Men and Transgender Women: HPTN 083.

Brown Todd T TT   Arao Robert F RF   Warsi Maryam M   Phanuphak Nittaya N   Vasconcelos Ricardo R   Oyedele Temitope T   Sullivan Philip A PA   Hanscom Brett B   Rooney James F JF   Rinehart Alex R AR   McCauley Marybeth M   Grinsztejn Beatriz B   Landovitz Raphael J RJ  

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20251201 5

In a randomized clinical trial, pre-exposure prophylaxis (PrEP) with long-acting cabotegravir (CAB-LA) had a better bone safety profile than tenofovir disoproxil fumarate-emtricitabine (TDF-FTC) over 105 weeks. For individuals with low bone mineral density or other fracture risk factors, CAB-LA PrEP should be considered over TDF-based PrEP. Clinical Trials Registration.  clinicaltrials.gov (NCT02720094). ...[more]

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