Bridging Genomics and Clinical Medicine: RSVrecon Enhances RSV Surveillance with Automated Genotyping and Clinically-important Mutation Reporting.

ABSTRACT:

Background

Respiratory Syncytial Virus (RSV) causes significant respiratory infections, particularly in young children and elderly adults. Genetic variations in the fusion (F) protein can reduce the efficacy of vaccination and monoclonal antibody treatments, emphasizing the need for genomic surveillance of this virus.

Motivation

Current pipelines for RSV genome assembly focus on sequence reconstruction but often lack features for detecting genotypes, clinically relevant mutations, or presenting results in formats that are suitable for clinical researchers.

Results

We introduce RSVrecon, an advanced bioinformatics pipeline for comprehensive RSV genome assembly and phylogenetic analysis. RSVrecon processes raw FASTQ files into annotated variant reports and delivers resu

SUBMITTER: Li L 

PROVIDER: S-EPMC12258908 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature