Shear Stress Induces a Time-Dependent Inflammatory Response in Human Monocyte-Derived Macrophages.

ABSTRACT: Macrophages are innate immune cells that are known for their extreme plasticity, enabling diverse phenotypes that lie on a continuum. In a simplified model, they switch between pro-inflammatory (M1) and anti-inflammatory (M2) phenotypes depending on surrounding microenvironmental cues, which have been implicated in disease outcomes. Although considerable research has been focused on macrophage response to biochemical cues and mechanical signals, there is a scarcity of knowledge surrounding their behavior in response to shear stress. In this study, we applied varying magnitudes of shear stress on human monocyte-derived macrophages (MDMs) using a cone-and-plate viscometer and evaluated changes in morphology, gene expression, protein expression, and cytokine secretion over time. MDMs exposed

SUBMITTER: Jui E 

PROVIDER: S-EPMC12263115 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature