CD317 stabilizes TNFR1 and confers the anti-inflammatory functions of MSCs via NF-κB/TSG6 pathway.

ABSTRACT:

Background

Although both pre-clinical and clinical studies show promising outcomes, resulting in rapid growth of clinical trials of MSC-based therapies in recent years, the heterogeneity and therapeutic inconsistency of MSCs have severely hampered their clinical applications. Purifying homogenous MSC populations with enhanced specific functions represents one promising approach. We have demonstrated recently that the CD317⁺ MSCs have enhanced anti-inflammatory functions and improved therapeutic efficacy and consistency.

Methods

In the current study, we performed both in vitro and in vivo investigations to delineate whether and how CD317 regulates the immune modulation function of MSCs.

Results

Our data here indicate that the CD317 directly contributes to th

SUBMITTER: Chen S 

PROVIDER: S-EPMC12282008 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature