Intra-articular injections for knee osteoarthritis management: Analysis of cost-effectiveness.

ABSTRACT:

Objective

Intra-articular injections (IAI) are commonly used to treat knee pain in persons with knee osteoarthritis (OA). We sought to determine the value of commonly used IAIs in knee OA management.

Methods

We used the validated Osteoarthritis Policy Model (OAPol) to assess the value of saline, corticosteroid (CS), hyaluronic acid (HA), and platelet-rich plasma (PRP) IAIs in knee OA management. We conducted a meta-analysis of high quality studies to estimate IAI-specific pain reduction. We assumed that repeat CS injections increase the risk of OA progression threefold in the base case. We determined the value of specific IAIs with incremental cost-effectiveness ratios (ICERs). We conducted sensitivity analyses to account for uncertainty in input parameters.

Results

I

SUBMITTER: Mass H 

PROVIDER: S-EPMC12284352 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature