Nipah virus vaccines evaluated in pigs as a 'One Health' approach to protect public health.

ABSTRACT: Nipah virus (NiV) causes a severe neurological disease in humans. The first NiV outbreak, in Malaysia, involved pig-to-human transmission, that resulted in significant economic losses to the local pig industry. Despite the risk NiV poses to pig-dense regions, no licensed vaccines exist. This study therefore assessed three NiV vaccine candidates in pigs: (1) adjuvanted soluble NiV (s)G protein, (2) adjuvanted pre-fusion stabilised NiV (mcs)F protein, and (3) adenoviral vectored NiV G (ChAdOx1 NiV G). NiV sG induced the strongest neutralising antibody response, NiV mcsF induced antibodies best able to neutralise cell-cell fusion, whereas ChAdOx1 NiV G elicited CD8⁺ T-cell responses. Despite differences in immunogenicity, prime-boost immunisation with all candidates conferred a hig

SUBMITTER: McLean RK 

PROVIDER: S-EPMC12287429 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature