Preoperative MRI-based radiomics analysis of intra- and peritumoral regions for predicting CD3 expression in early cervical cancer.

ABSTRACT: The study investigates the correlation between CD3 T-cell expression levels and cervical cancer (CC) while developing a magnetic resonance (MR) imaging-based radiomics model for preoperative prediction of CD3 T-cell expression levels. Prognostic correlations between CD3D, CD3E, and CD3G gene expressions and various cancers were analyzed using the Cancer Genome Atlas (TCGA) database. Protein-protein interaction (PPI) analysis via the STRING database identified associations between these genes and T lymphocyte activity. Gene Set Enrichment Analysis (GSEA) revealed immune pathway enrichment by categorizing genes based on CD3D expression levels. Correlations between immune checkpoint molecules and CD3 complex genes were also assessed. The study retrospectively included 202 patients with pathol

SUBMITTER: Zhang R 

PROVIDER: S-EPMC12287529 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature