Early diuretic response and outcome prediction in ambulatory worsening heart failure: Natriuresis versus diuresis.

ABSTRACT:

Aims

Early diuresis and natriuresis are commonly used to assess the efficacy of decongestive therapy following an acute heart failure episode. There is limited knowledge regarding which parameter better predicts adverse clinical outcomes, especially in the outpatient setting. This study investigated the prognostic value of both metrics in predicting 30-day adverse clinical events in an ambulatory worsening heart failure (WHF) scenario.

Methods and results

This is a post-hoc analysis of the SALT-HF trial involving 167 patients with ambulatory WHF randomized to receive intravenous furosemide with or without hypertonic saline solution. Early diuretic response was assessed through 3-h urine output and 3-h urinary sodium (uNa⁺) levels following intravenous (IV) diureti

SUBMITTER: Cobo Marcos M 

PROVIDER: S-EPMC12287789 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature