Can we improve the diagnosis of invasion in encapsulated follicular-patterned thyroid tumors? Data from a massive international e-learning initiative.

ABSTRACT: With the reclassification of non-invasive follicular variant of papillary thyroid carcinoma as "tumors" (NIFTP), the challenge of diagnosing carcinoma lies in recognizing invasion: blood vessel invasion (BVI) or capsular invasion (CI). We aimed to assess reproducibility in diagnosing BVI and CI in follicular-patterned tumors using a web-platform, under conditions as close as possible to routine surgical pathology practice. Six-hundred-fourteen pathologists reviewed 69 thyroid lesions diagnostically challenging for BVI or CI, made available in three rounds: before, immediately after, and three months after a training lecture given by an expert pathologist. Each lesion was associated with a quiz (five queries: certain CI, doubtful CI, certain BVI, doubtful BVI, or no invasion). Intraobserver

SUBMITTER: Mansour Y 

PROVIDER: S-EPMC12289735 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature