Single-cell transcriptomics identifies PDGFRA⁺ progenitors orchestrating angiogenesis and periodontal tissue regeneration.

ABSTRACT: Periodontal bone defects, primarily caused by periodontitis, are highly prevalent in clinical settings and manifest as bone fenestration, dehiscence, or attachment loss, presenting a significant challenge to oral health. In regenerative medicine, harnessing developmental principles for tissue repair offers promising therapeutic potential. Of particular interest is the condensation of progenitor cells, an essential event in organogenesis that has inspired clinically effective cell aggregation approaches in dental regeneration. However, the precise cellular coordination mechanisms during condensation and regeneration remain elusive. Here, taking the tooth as a model organ, we employed single-cell RNA sequencing to dissect the cellular composition and heterogeneity of human dental follicle an

SUBMITTER: Liu J 

PROVIDER: S-EPMC12289874 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature