Microbiota Transplantation Among Patients Receiving Long-Term Care: The Sentinel REACT Nonrandomized Clinical Trial.

ABSTRACT:

Importance

Intestinal multidrug-resistant organism (MDRO) colonization is highly prevalent in long-term acute care hospital (LTACH) patients and is associated with MDRO infection and transmission. However, there are no therapies approved by the US Food and Drug Administration to reduce intestinal MDRO colonization.

Objective

To determine the safety and acceptability of fecal microbiota transplantation (FMT) in LTACH patients.

Design, setting, and participants

This single-center, open-label nonrandomized clinical trial was conducted from April to December 2023 at an LTACH in the Southeastern US with median 50-patient census and 28-day length of stay. Patients with MDRO colonization were identified by perirectal prevalence sampling. Patients colonized with at least 1 ta

SUBMITTER: Woodworth MH 

PROVIDER: S-EPMC12290730 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature