Infrared and Raman spectroscopy of blood plasma for rapid endometrial cancer detection.

ABSTRACT:

Background

Endometrial cancer (EC) is the 6th most common cancer among women worldwide. No effective non-invasive screening methods or approved blood biomarkers for EC exist. Previous research explored Attenuated Total Reflection-Fourier Transform Infrared (ATR-FtIR) and Raman spectroscopies, using dried blood plasma. Fresh, 'wet', blood samples, that might provide faster results, have not been investigated. This study compared ATR-FtIR and Raman spectroscopies on 'wet' and dry blood plasma samples for EC detection. It also conducted a preliminary exploration into their diagnostic potential for EC in high-risk individuals with polycystic ovary syndrome (PCOS).

Methods

'Wet' and dry blood plasma samples from participants with EC, PCOS and healthy controls were analysed using

SUBMITTER: Schiemer R 

PROVIDER: S-EPMC12304263 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature