Disrupted Glucose Metabolism Covariance Network in Amyotrophic Lateral Sclerosis.

ABSTRACT:

Aims

This study aimed to characterize the topological changes in glucose metabolism covariance networks in amyotrophic lateral sclerosis (ALS).

Methods

We assessed the interregional coordination of ¹⁸F-FDG-PET data to examine topological alterations in individualized glucose metabolism covariance networks in 127 ALS patients compared to 128 healthy controls (HC).

Results

Compared to HC, ALS patients showed reduced small-worldness (lower normalized clustering coefficient, higher normalized characteristic path length) and decreased global and local efficiency, suggesting impaired global integration and local segregation. These network metrics correlated with disease progression and motor function. Regionally, altered degree centrality affected motor and defau

SUBMITTER: Jin X 

PROVIDER: S-EPMC12304423 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature