The Progression of NUS1-Associated Parkinson's Disease and the Diagnostic Potential of Plasma NgBR.

ABSTRACT:

Aims

The study aimed to investigate the role of NUS1 variants in Parkinson's disease (PD) progression and evaluate plasma Nogo-B receptor (NgBR) as a potential biomarker.

Methods

We recruited 228 PD patients, including 38 with NUS1 variants (NUS1-PD) and 190 without (GU-PD), and all underwent at least two follow-up visits. Linear mixed-effects models assessed motor and non-motor symptom progression. Plasma NgBR levels were measured in PD, Multiple System Atrophy (MSA), Progressive Supranuclear Palsy (PSP), and healthy controls (HC), and receiver operating characteristic curve analysis evaluated its diagnostic efficacy.

Results

NUS1-PD demonstrated an earlier age at onset and more severe motor features than GU-PD at baseline. Longitudinal analyses showed similar progre

SUBMITTER: Li L 

PROVIDER: S-EPMC12304428 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature