Human amylin is a potent antimicrobial peptide that exhibits antimicrobial synergism with the amyloid beta protein.

ABSTRACT:

Introduction

Our previous studies demonstrated the antimicrobial properties of amyloid beta (Aβ) of Alzheimer's disease (AD) against clinically relevant bacteria, yeast, and viruses. In this study, we investigate the antimicrobial function of the 37-amino acid amylin of type 2 diabetes (T2D), expanding on its potential involvement in AD.

Methods

We used in vitro assays, including human three-dimensional neuronal cell culture models, to test microbicidal, microbiostatic, and synergistic antimicrobial interactions between amylin and Aβ against microbes.

Results

Our results confirm that amylin is a broad-spectrum antimicrobial peptide that exhibits both microbicidal and microbiostatic mechanisms. We also identified a synergistic antimicrobial effect between amylin and Aβ

SUBMITTER: Vijaya Kumar DK 

PROVIDER: S-EPMC12307129 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature