Data-Driven Approach to Dynamic Resting State Functional Connectivity in Post-Traumatic Stress Disorder: An ENIGMA-PGC PTSD Study.

ABSTRACT: Using functional magnetic resonance imaging (fMRI), symptoms of posttraumatic stress disorder (PTSD) have been associated with aberrations in brain networks in the absence of a given cognitive demand or task, called resting-state networks. Prior work has focused on disruption in the static functional connectivity (FC) among specific regions constrained by a priori hypotheses. However, dynamic FC, an approach that examines brain network characteristics over time, may provide a more sensitive measure to understand the network properties underlying dysfunction in PTSD. Further, using a data-driven analytic approach may reveal the contribution of other larger network disturbances beyond those revealed by hypothesis-driven examinations of ROIs or canonical networks. Therefore, the current study

SUBMITTER: Tomas CW 

PROVIDER: S-EPMC12308910 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature